Search Tag: Sepsis
2024 16 Sep
Mechanical ventilation (MV) can be both beneficial and harmful for critically ill patients. It improves gas exchange, reduces the work of breathing, and lowers self-inflicted lung injury risk. MV, often accompanied by sedatives and neuromuscular blockers, can also reduce oxygen consumption and carbon dioxide production, and in patients with cardiac...Read more
2024 02 Sep
A recent review addresses the challenge of categorising new persistent symptoms that patients experience after recovering from ICU-treated sepsis caused by COVID-19. It explores whether these symptoms fit into one of the following categories: Long-COVID, Post-Sepsis Syndrome, or Post-Intensive-Care Syndrome. It also considers if patients might...Read more
2024 29 Aug
A new artificial intelligence tool, SepsisLab, has been developed to assist clinicians in making decisions about hospital patients at risk for sepsis, with a distinctive feature: it acknowledges its uncertainty. It indicates which demographic data, vital signs, and lab test results are needed to enhance its predictive accuracy. The research was published...Read more
2024 05 Aug
Sepsis is a life-threatening organ dysfunction caused by a dysregulated response to infection. It is responsible for approximately 50 million cases and 11 million deaths worldwide, accounting for about 20% of all global deaths. The challenge in accurately estimating sepsis and its associated mortality stems from varying definitions, diagnostic...Read more
2024 24 Jul
Sepsis is a global health issue with high mortality and morbidity rates among hospitalised patients. To enhance the quality of sepsis management, the Surviving Sepsis Campaign (SSC) developed an evidence-based bundle comprising five key elements to be implemented within the first hours of sepsis recognition. These elements include fluid resuscitation...Read more
2024 22 Jul
The clinical course and outcomes of sepsis vary widely, but early recognition and intervention with fluids, vasoactive agents, and antimicrobials significantly reduce morbidity and mortality. However, beyond supportive care, therapeutic options for sepsis are limited. Many biomarkers are associated with sepsis severity and outcomes, but their...Read more
2024 17 Jul
Critical care has traditionally focused on clinical practice and research around syndromes such as sepsis, acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), and traumatic brain injury (TBI). However, these syndromes, while familiar to clinicians, are inherently diverse and encompass various pathophysiological processes that...Read more
2024 03 Jul
Sepsis and septic shock, caused by a dysregulated response to infection, affect nearly 50 million people globally, resulting in approximately 11 million deaths. Early identification and management, including source control, antimicrobial therapy, and fluid resuscitation, are associated with reduced mortality. The Surviving Sepsis Campaign (SSC)...Read more
2024 02 Jul
Sepsis is a life-threatening condition caused by a dysregulated host response to infection. The Sepsis-related Organ Failure Assessment (SOFA) score, developed in 1996, quantifies organ dysfunction across six systems: neurological, cardiovascular, respiratory, renal, liver, and coagulation. Initially specific to sepsis, the SOFA score is widely...Read more
2024 23 Jun
Sepsis can progress to multiple organ dysfunction syndrome or multiorgan failure. Globally, sepsis-related deaths are estimated at 11 million annually, representing 19.7% of total deaths, with a global age-standardised death rate of 148.1 per 100,000 people. Despite advancements in treatment, the case fatality rate for sepsis remains high at 30%...Read more
2024 23 Jun
A new study aimed to determine if continuous infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) reduces all-cause mortality at 90 days compared to intermittent infusion in critically ill patients with sepsis. The BLING III randomised clinical trial was conducted across 104 ICUs in Australia, Belgium, France, Malaysia,...Read more
2024 21 Jun
Patients with sepsis could be treated based on their immune system’s response to infection rather than their symptoms. New research has revealed that people’s genetic makeup significantly influences their response to sepsis. This understanding could help identify those who would benefit from specific treatments and pave the way for developing...Read more
2024 15 Jun
Sepsis is a life-threatening complication causing nearly 1.7 million hospitalisations and 350,000 deaths annually in the U.S. Rapid and accurate diagnosis is critical, as the risk of mortality increases by up to 8% for each hour that effective treatment is delayed. Currently, the diagnostic standard relies on culture growth, which typically takes...Read more
2024 13 Jun
A new study published in Microbiology Spectrum reveals that the nasal microbiota of ICU patients can effectively distinguish between sepsis and non-sepsis cases, outperforming gut microbiota in predicting sepsis. These findings have implications for developing diagnostic strategies and advancing critical care medicine. Historically, the focus...Read more
2024 04 Jun
Sepsis is a severe condition characterised by organ dysfunction due to impaired oxygen delivery and utilisation by cells. In ICUs, oxygen is often administered to sepsis patients, especially those with sepsis-induced hypoxaemic respiratory failure. Traditionally, the goal is to maintain a partial pressure of oxygen in arterial blood (PaO2) around...Read more
2024 01 Jun
Sepsis is a major cause of death and disability and a key focus of quality measures for hospitals. In-hospital mortality of sepsis patients is often used for benchmarking by researchers and policymakers. For instance, in New York, sepsis regulations require reporting risk-adjusted in-hospital mortality, identifying hospitals with higher or lower...Read more
2024 28 May
Sepsis causes 11 million deaths annually and is linked to post-intensive care syndrome (PICS), which includes physical impairment, reduced quality of life, and posttraumatic stress syndrome. Despite multidisciplinary interventions, up to 61.4% of sepsis patients experience physical impairment at hospital discharge. This is a significant outcome...Read more
2024 22 May
Acetaminophen (paracetamol) has several pharmacological effects that are potentially beneficial in sepsis, including analgesia, antipyresis, and cyclooxygenase-2 inhibition. Observational studies and small clinical trials suggest acetaminophen improves survival and kidney function in sepsis patients with elevated cell-free haemoglobin. However,...Read more
2024 16 May
Sepsis affects approximately 49 million people worldwide each year. To reduce the mortality rate and the global burden of sepsis, the World Health Organization has classified it as a priority research area. When combined with surgical trauma, anaesthetic drugs, and various invasive procedures, the impact intensifies, leading to further impairment...Read more
2024 14 May
Critical illness-related corticosteroid insufficiency (CIRCI) is commonly seen in criticall ill patients and involves systemic inflammation, hypothalamus–pituitary–adrenal axis dysregulation, altered cortisol metabolism, and tissue glucocorticoid resistance. A task force of international experts from the Society of Critical Care Medicine...Read more
2024 08 May
A recent study conducted by the University of Gothenburg involving over a million newborns in Sweden highlights a concerning trend: despite a notable decrease in the rate of sepsis among this group, the administration of antibiotics remains disproportionately high. The study, published in JAMA, highlights the need for a reevaluation of antibiotic...Read more
2024 30 Apr
A recent study investigates the clinical factors influencing clinician decisions regarding fluid administration, vasopressor initiation, and vasopressor route in early sepsis. Previous concerns about fluid overload in sepsis have prompted interest in early vasopressor initiation, especially through peripheral IVs, as an alternative to central lines....Read more
2024 21 Apr
Sepsis is a Medical Emergency Requiring Immediate Diagnosis & Treatment Pancreatic Stone Protein (PSP) on the abioSCOPE® is the Earliest Marker of Sepsis Sepsis is a major healthcare burden claiming more than 11 million lives per year, one death every 2.8 seconds 1 . It is caused by a dysregulated host response to infection which...Read more
2024 21 Apr
Sepsis is a Medical Emergency Requiring Immediate Diagnosis & Treatment Pancreatic Stone Protein (PSP) on the abioSCOPE® is the Earliest Marker of Sepsis Sepsis is a major healthcare burden claiming more than 11 million lives per year, one death every 2.8 seconds 1 . It is caused by a dysregulated host response to infection which...Read more
2024 02 Apr
A recent review explores the crucial role of hypoxia-inducible factor-1α (HIF-1α) in the development and progression of sepsis. Hypoxia-inducible factor (HIF) is a protein complex consisting of a constitutively expressed subunit β and an oxygen-dependent subunit α. HIF-1α is associated with acute hypoxia and regulates glycolytic genes, oxygen...Read more
2024 26 Mar
Sepsis remains a major cause of mortality, accounting for nearly 20% of global deaths. Microcirculatory dysfunction, marked by irregular blood flow and increased permeability of blood vessels, is a characteristic feature of sepsis. This dysfunction can lead to tissue swelling and impaired organ function. Endothelial dysfunction, which is also seen...Read more