Search Tag: RCTs

2024 23 Sep

Traditional explanatory randomised controlled trials (RCTs), often used for drug or device approval, assess interventions under ideal conditions but may not reflect real-world clinical practice, as they typically involve younger patients with fewer coexisting conditions. These trials also struggle to detect treatment effect differences among subgroups...Read more

2016 22 May

Results of the Early vs Late Initiation of Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury (ELAIN) Trial found a significant reduction in 90-day all-cause mortality in the early initiation group. The single-centre study, by Alexander Zarbock , MD, of University Hospital Munster, Germany, and colleagues, which is to be...Read more

2016 07 Jan

Rigid adherence to evidence-based medicine does not serve healthcare well, according to the authors of a review published in Health Research Policy and Systems . The tools that are suitable for discovery are unsuitable when it comes to implementation in healthcare services, they suggest. Health is a complex interaction requiring complex science techniques,...Read more