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Sepsis Diagnosis: Clinical Signs, Scores, and Biomarkers
Abstract Sepsis and antimicrobial resistance are two major public health problems . Sepsis is defined as a dysregulated response of the body to a bacterial infection with organ dysfunction . The 2021 Surviving Sepsis Campaign SSC guidelines proposed characterising the infection based on clinical assessment and the dysregulated...
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Sepsis Diagnosis: Pancreatic Stone Protein in Adults, Children, and Neonates
Based on the concepts and the checklist criteria for an ideal sepsis biomarker presented in the article Sepsis Diagnosis: Clinical signs, Scores, and Biomarkers in this issue of ICU Management & Practice , we update and review the potential use of Pancreatic Stone Protein (PSP) in adults, children, and neonates. Pancreatic Stone...
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Tachycardia in Sepsis: Friend or Foe?
An overview of tachycardia in sepsis, the importance of rate control and the beneficial effects of beta-blockers. Sepsis and Tachycardia – Aetiologic Factors During sepsis, the sympathetic nervous system plays a key role in maintaining cardiac output and blood pressure. This is achieved through changes...
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Improving Haemodynamic Management of ICU Patients: Decatecholaminisation & Cardiac Stress Reduction
A summary of a symposium organised by AOP Health with presentations from Ricard Ferrer, Vall d’Hebron University Hospital, Barcelona, Spain; Bruno Levy, Centre Hospitalier Universitaire de Nancy, CHU Nancy · Réanimation Médicale Brabois, France; and Michael Fries, St. Vincenz Krankenhaus Limburg, Department of Anesthesiology, Germany....
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The Clinical Utility of Estimated Plasma Volume in Critical Care
An overview of clinical evidence that demonstrates the prognostic value of estimated plasma volume (ePVS) in critically ill patients. Relevance Plasma volume (PV) is the total volume of blood plasma – the extracellular fluid volume of the vascular space. It is associated with regulating interstitial and intravascular spaces; hence it can...
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Guiding Clinical Care Using Pancreatic Stone Protein
The role of point-of-care testing in the early identification and management of sepsis, the need for better markers to identify sepsis, an overview of the Pancreatic Stone Protein (PSP) and clinical evidence highlighting its effectiveness as a biomarker. Pancreatic Stone Protein Infections are a leading cause of morbidity and mortality...
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Pancreatic Stone Protein Biomarker for Sepsis, Antimicrobial Resistance and Nosocomial Infections
The problem of antimicrobial resistance and the use of a clinical decision score and point-of-care testing biomarkers, such as CRP and PSP, to help solve this problem. Introduction Infectious diseases are a public health issue around the world, with bacterial, viral, parasitic, or fungal-related diseases responsible for 26% of mortality...
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Improving Clinical Outcomes With Early Enteral Nutrition
An overview of the benefits of early enteral nutrition, clinical evidence and recommendations, reasons for delayed enteral feeding in critically ill patients and optimal solutions. Early enteral nutrition is proven to improve clinical outcomes and reduce acute care costs. Nutrition clinicians support the belief that enteral nutrition is...
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Short Acting Beta-Blockers in Critically Ill Patients With Heart Failure
An overview of the clinical evidence demonstrating the effectiveness of landiolol for the treatment of atrial fibrillation or atrial flutter with heart failure and effective heart rate control during arrhythmias. Supraventricular arrhythmias (SVTs) are common in post-operative and cardiac ICUs. SVTs increase the risk of death...
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Practical Implementation of the Pancreatic Stone Protein Sepsis Test
An overview of a discussion on sepsis and the Pancreatic Stone Protein (PSP) biomarker by Dr João Pereira, Hospital De Vila Franca De Xira, Portugal and how it can be used for early diagnosis of sepsis and facilitate decision-making regarding the administration of antibiotics. The discussion was chaired by Prof Pedro Póvoa, coordinator of...
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Nutrition Monitoring and Patient Data Management Systems
An overview of nutritional targets and their impact on critically ill patients and the need to use a systematic approach to nutritional support for optimal patient outcomes. Critically ill patients are often hypermetabolic and catabolic and are at a higher risk of underfeeding. Nutritional support for these patients can prevent energy...
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